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Publications

2023

S.D. Burz, S. Čaušević, et al. (incl. A.R. Pacheco). From microbiome composition to functional engineering, one step at a time. Microbiology and Molecular Biology Reviews (2023). [View]

M. Schäfer*, A.R. Pacheco*, R. Künzler, M. Bortfeld-Miller, C.M. Field, E. Vayena, V. Hatzimanikatis, and J.A. Vorholt. Metabolic interaction models recapitulate leaf microbiota ecology. Science 380, eadf5121 (2023). [View] *Contributed equally

A.R. Pacheco and J.A. Vorholt. Resolving metabolic interaction mechanisms in plant microbiomes. Current Opinion in Microbiology 74, 102317 (2023). [View]

2022

A.R. Pacheco*, C. Pauvert*, D. Kishore, and D. Segrè. Toward FAIR representations of microbial interactions. mSystems e00659-22 (2022). [View] *Contributed equally

2021

N. Ankrah, D.B. Bernstein, M. Biggs, M. Carey, M. Engevik, B. García-Jiménez, M. Lakshmanan, A.R. Pacheco, S. Sulheim, and G. Medlock. Enhancing microbiome research through trustworthy genome-scale metabolic modeling. mSystems 6,6 (2021). [View]

I. Dukovski, D. Bajić, J.M. Chacón, M. Quintin, J.C.C. Vila, S. Sulheim, A.R. Pacheco, D.B. Bernstein, W.J. Riehl, K.S. Korolev, A. Sanchez, W.R. Harcombe, and D. Segrè. A metabolic modeling platform for the computation of microbial ecosystems in time and space (COMETS). Nature Protocols 16, 5020-5082 (2021). [View]

D.C. Moyer, A.R. Pacheco, D.B. Bernstein, and D. Segrè. Stoichiometric Modeling of Artificial String Chemistries Reveals Constraints on Metabolic Network Structure. Journal of Molecular Evolution 89, 472-483 (2021). [View]

A.R. Pacheco and D. Segrè. An evolutionary algorithm for designing microbial communities via environmental modification. J. R. Soc. Interface 18, 20210348 (2021). [View]

A.R. Pacheco, M.L. Osborne, and D. Segrè. Non-additive microbial community responses to environmental complexity. Nature Communications 12, 2365 (2021). [View]

2019

A.R. Pacheco and D. Segrè. A multidimensional perspective on microbial interactions. FEMS Microbiology Letters 366, 1–11 (2019). [View]

A.R. Pacheco, M. Moel, and D. Segrè. Costless metabolic secretions as drivers of interspecies interactions in microbial ecosystems. Nature Communications 10, 103 (2019). [View]

2015-2018

B.M. Maoz, A. Herland, E.A. FitzGerald, T. Grevesse, C. Vidoulez, A.R. Pacheco, S.P. Sheehy, T.E. Park, S. Dauth, R. Mannix, N. Budnik, K. Shores, A. Cho, J.C. Nawroth, D. Segrè, B. Budnik, D.E. Ingber, and K.K. Parker. Endothelial-neuronal cell metabolic coupling across the blood-brain barrier revealed using linked human organs-on-chips. Nature Biotechnology 36, 865–874 (2018). [View]

J. Beal, T. Haddock-Angelli, M. Gershater, K. de Mora, M. Lizarazo, J. Hollenhorst, R. Rettberg, iGEM Interlab Study Contributors (incl. A.R. Pacheco). Reproducibility of Fluorescent Expression from Engineered Biological Constructs in E. coli. PLOS ONE 11, e0150182 (2016). [View]

T. Haddock, D. Densmore, E. Appleton, S. Carr, S. Iverson, A.R. Pacheco, et al. The Modular Cloning Assembly: Standardized Assembly of Bacterial Transcriptional Units Using Type IIS Restriction Enzymes BsaI and BpiI. The BioBricks Foundation RFC 94 (2015). [View]

Ph.D. Thesis

A.R. Pacheco. Environmental modulation of microbial ecosystems. (2021). [View]